Her youngest was only 3 at the time, and she remembers bending down to bathe him and feeling a sharp pain in her back.
Perlis’ symptoms accumulated and intensified – her back pain became more constant, she was feeling itchy and noticed that her urine was dark in color. But it was when a friend at her son’s preschool observed that her eyes were looking yellow that Perlis went to the doctor for some bloodwork.
“I remember being told that my bilirubin was high, causing the jaundice,” Perlis said. “The most logical explanation was gallstones, but none were visible on an ultrasound.”
Instead, additional imaging revealed a mass on her pancreas.
Perlis, 36 at the time, instantly worried about upsetting her children. “I wanted a better sense of what we were up against,” she recalled.
“Instead of seeing shrinkage of the tumor on my pancreas, the scan revealed new cancer growth on my liver,” Perlis said.
“I was now a stage IV pancreatic cancer patient and no longer eligible for surgery.”
Perlis’ new doctor recommended molecular profiling – a test to determine whether her tumor tissue had biological characteristics that may help guide the best treatment options for her.
“My molecular profiling report came back showing that my tumor has a BRCA2 mutation,” Perlis said. “We were encouraged to learn that BRCA-mutant tumors often respond well to platinum-based chemotherapies, and one of the components of FOLFIRINOX contains platinum.”
Indeed, Perlis’ tumors shrank markedly after about four months of FOLFIRINOX treatments. She and her family then learned of another type of treatment, a targeted therapy called a PARP inhibitor, that has also shown promise in patients whose tumors had a BRCA mutation.
“The PARP inhibitor made my liver tumors essentially disappear,” Perlis recalled. “We returned to my surgeon and asked whether surgery was back on the table as an option.”
She continued, “My surgeon admitted it was an unorthodox approach, but he agreed, and I ended up having a successful Whipple procedure in April 2018.”
Just two short months later, she and her family and friends participated in PurpleStride Washington, D.C., the walk to end pancreatic cancer. “Our team raised more than $12,000 to support PanCAN [the Pancreatic Cancer Action Network],” Perlis said, “and I was so grateful for the outpouring of love and generosity.”
Throughout this entire experience, Perlis and her husband Aaron emphasize the importance of their community. “We have been supported greatly by family, friends, work, our synagogue and PanCAN,” Aaron noted.
When asked what advice she’d provide someone newly diagnosed with pancreatic cancer, Perlis emphasized: “Stay positive – it’s contagious. There’s so much hope, so many new studies happening all the time.”
Any treatments, including clinical trials, mentioned in this story may not be appropriate or available for all patients. Doctors take many things into account when prescribing treatments including the stage and type of cancer and the overall health of the patient. Contact Patient Central for personalized treatment options.