Patients treated with matched therapies selected through molecular profiling have better outcomes1. The Pancreatic Cancer Action Network supports the guidelines’ recommendations to obtain tumor tissue suitable for molecular profiling. PanCAN offers information and resources related to precision medicine, including the Know Your Tumor precision medicine service, for you and your patients.

1PanCAN's Public Statements for Healthcare Professionals, including references.

Valuable Information to Support Your Treatment Decisions

There is no roadmap for treating pancreatic cancer. We are learning more about the disease, and new information is discovered every day. What has become clear: Pancreatic cancer is heterogeneous and should be treated based on the biology of a patient’s tumor. Our Know Your Tumor service, provided in partnership with Perthera, gives you molecular information about your patient’s tumor.

“Know Your Tumor is a very important effort to improve the care provided to pancreatic cancer patients. We gain an important understanding of tumor biology, which leads to more precise selection of treatments. This is personalized medicine at its best.”

— Dr. Andrew E. Hendifar
Medical oncology lead for the gastrointestinal disease research group at Cedars-Sinai Medical Center

More Treatment Options

The Know Your Tumor report includes treatment options, which are determined after report findings are interpreted by an expert panel, providing valuable insight to support your treatment decisions.

Treatment options, personalized to your patient, may include:

  • Targeted therapy, which avoids the toxicity of multi-agent chemotherapy

  • Appropriate clinical trials, including molecularly targeted solid tumor trials

  • Off-label treatments that may be particularly effective for your patient’s specific tumor mutations

  • Standard of care treatments

Our Trusted Partner

The Pancreatic Cancer Action Network (PanCAN) partners with a comprehensive precision medicine company, Perthera, that combines advanced molecular diagnostic testing, including genomic profiling and proteomic analysis, through CLIA-Certified laboratories. Perthera creates your patient’s report using a proprietary Expert Oncology platform, patient history analysis, the molecular profile of the patient’s tumor and board-certified oncologist input.

The Know Your Tumor Process

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More than 400 physicians – from institutions such as Cedars-Sinai Medical Center, Johns Hopkins, Virginia Mason Medical Center and Memorial Sloan-Kettering – have received Know Your Tumor reports for their patients. About 27 percent of patients’ tumors have been found to have at least one actionable alteration.


The following criteria will help you decide which patients are best suited for Know Your Tumor:

  • Patient has diagnosis of pancreatic malignancy

  • Tumor tissue is obtainable

    • Newly obtained core biopsy, 4 – 6 cores with 18 – 20 gauge needle preferred

      • From accessible metastatic site

      • From primary site, if biopsy acquisition is deemed an acceptable risk

    • Surgical specimen

      • If post-surgery, within 12 months of resection with no other source of tissue available

  • Patient has no sign of progression or impending need to change treatment

    • Completion and delivery of the report takes approximately 25 – 45 days from receipt of tissue

  • Patient resides in the United States or Canada and is not imprisoned

  • Patient or close caregiver reads and speaks English or Spanish

Start the Process for Your Pancreatic Cancer Patient

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Our Patient Central Associates can discuss Know Your Tumor and answer any questions you have.
Associates are available M – F, 7 a.m. – 5 p.m. PT.

Know Your Tumor Resources

Accelerating Pancreatic Cancer Research

The Pancreatic Cancer Action Network has created the Patient Registry, an online global database, to look for patterns in treatments, side effect management and diagnostics that will lead to improved treatment options and patient outcomes. Patients and caregivers share their experiences and their Know Your Tumor reports in this registry, helping researchers learn more about the commonalities in the makeup of pancreatic tumors to focus their efforts on highly prevalent biomarkers.

Other Relevant Resources

  • Clinical Trial Finder

    Quickly and easily access information from the most comprehensive and up-to-date database of pancreatic cancer clinical trials available in the U.S.

  • Publications

    See the research we have published to contribute to the advancement of the pancreatic cancer field.

  • Free Patient Education Materials

    Order free materials to help educate your patients about various topics related to pancreatic cancer, including clinical trials and diet and nutrition.